Bottom-up and top-down paradigms of artificial intelligence research approaches to healthcare data science using growing real-world big data.

OBJECTIVES: As the real-world electronic health record (EHR) data continue to grow exponentially, novel methodologies involving artificial intelligence (AI) are becoming increasingly applied to enable efficient data-driven learning and, ultimately, to advance healthcare. Our objective is to provide readers with an understanding of evolving computational methods and help in deciding on methods to pursue. TARGET AUDIENCE: The sheer diversity of existing methods presents a challenge for health scientists who are beginning to apply computational methods to their research. Therefore, this tutorial is aimed at scientists working with EHR data who are early entrants into the field of applying AI methodologies. SCOPE: This manuscript describes the diverse and growing AI research approaches in healthcare data science and categorizes them into 2 distinct paradigms, the bottom-up and top-down paradigms to provide health scientists venturing into artificial intelligent research with an understanding of the evolving computational methods and help in deciding on methods to pursue through the lens of real-world healthcare data.

Analysis of COVID-19 Vaccinations and Symptom Mapping Diagnostic Technique for Viral Diseases: Using Data Analytics, Machine Learning, and Artificial Intelligence.

To analyze, understand, and measure the COVID-19 vaccination outlook in a developing country as Nigeria; and the non-clinical analysis, diagnosis, treatment and management of COVID-19, and other Viral Diseases, using Data/Machine Learning (ML)/Artificial Intelligence (AI), Analytical Tools, and Methodologies. Using current and historical data from validated open source data stores, analysis was carried out on COVID-19 vaccination and related economic, demographic, and geo-climatic data for a developing country, Nigeria and selected countries from all continents of the world. The methodical and data-driven analyses were carried out using the following Data/Artificial Intelligence (AI) methodologies and algorithms: Excel Data Analytics, Multivariate Linear Regression Analysis method in Machine Learning (ML) Engineering, Symptom Mapping Analysis, Gray System Analysis. The COVID-19 vaccinations expectedly does reduce the number of active COVID cases and the amount or number of vaccinations for a developing country as Nigeria is affected by a good number of economic, demographic, and geo-climatic factors; and so COVID-19 vaccinations strategies must be unique to a country and categories of countries and take into account influencing factors not only limited to number of active COVID cases. The strategies (including vaccinations roll-out) to eliminate COVID-19 can be better understood and managed for increased productivity and faster success rate in the fight against COVID-19. Medical practitioners can provide even more efficient diagnosis and treatment of viral diseases; and also patients can carry out personalized cost effective diagnosis and treatment/management of viral diseases, with also the advises of medical practitioners.

Public Perception Before and After COVID-19 Vaccine Pass for the Unvaccinated to Eat Alone: Social Media Data Analytics.

This study was conducted to compare the trends of public perception in South Korea about the vaccine pass requiring the unvaccinated to eat alone during the COVID-19 crisis. Data were collected via Text mining; frequency, association, and sentiment analysis using the social big data analysis service, (known as "Some-Trend"), 2 months before and after December 16, 2021, when the vaccine pass was announced. The total number of search results was 4899 occurrences of the keywords using "eating alone" and "Hon-bab" (Korean abbreviation for eating alone). During the week of December 16, the frequency was the highest (770 occurrences). Compared to the weeks before the announcement sentiment analysis shows that words including "Reject," "Discrimination," and "Uncomfortable," among others, either newly appeared or increased in frequency. And also, the percentage of positive words decreased from 54.5% to 34% and that of negative words increased from 30.2% to 43.3%. The introduction of the vaccine pass has raised negative public interest, particularly regarding the policy of unvaccinated people forcefully restricted to eat alone. Accordingly, this study showed that the vaccine policy had not gain positive perception of the public.

Exploring the Potential of Big Data Analytics in Urban Epidemiology Control: A Comprehensive Study Using CiteSpace.

In recent years, there has been a growing amount of discussion on the use of big data to prevent and treat pandemics. The current research aimed to use CiteSpace (CS) visual analysis to uncover research and development trends, to help academics decide on future research and to create a framework for enterprises and organizations in order to plan for the growth of big data-based epidemic control. First, a total of 202 original papers were retrieved from Web of Science (WOS) using a complete list and analyzed using CS scientometric software. The CS parameters included the date range (from 2011 to 2022, a 1-year slice for co-authorship as well as for the co-accordance assessment), visualization (to show the fully integrated networks), specific selection criteria (the top 20 percent), node form (author, institution, region, reference cited, referred author, journal, and keywords), and pruning (pathfinder, slicing network). Lastly, the correlation of data was explored and the findings of the visualization analysis of big data pandemic control research were presented. According to the findings, "COVID-19 infection" was the hottest cluster with 31 references in 2020, while "Internet of things (IoT) platform and unified health algorithm" was the emerging research topic with 15 citations. "Influenza, internet, China, human mobility, and province" were the emerging keywords in the year 2021-2022 with strength of 1.61 to 1.2. The Chinese Academy of Sciences was the top institution, which collaborated with 15 other organizations. Qadri and Wilson were the top authors in this field. The Lancet journal accepted the most papers in this field, while the United States, China, and Europe accounted for the bulk of articles in this research. The research showed how big data may help us to better understand and control pandemics.

Beyond the Digital Competencies of Medical Students: Concerns over Integrating Data Science Basics into the Medical Curriculum.

Introduction. Data science is becoming increasingly prominent in the medical profession, in the face of the COVID-19 pandemic, presenting additional challenges and opportunities for medical education. We retrospectively appraised the existing biomedical informatics (BMI) and biostatistics courses taught to students enrolled in a six-year medical program. Methods. An anonymous cross-sectional survey was conducted among 121 students in their fourth year, with regard to the courses they previously attended, in contrast with the ongoing emergency medicine (EM) course during the first semester of the academic year 2020−2021, when all activities went online. The questionnaire included opinion items about courses and self-assessed knowledge, and questions probing into the respondents' familiarity with the basics of data science. Results. Appreciation of the EM course was high, with a median (IQR) score of 9 (7−10) on a scale from 1 to 10. The overall scores for the BMI and biostatistics were 7 (5−9) and 8 (5−9), respectively. These latter scores were strongly correlated (Spearman correlation coefficient R = 0.869, p < 0.001). We found no correlation between measured and self-assessed knowledge of data science (R = 0.107, p = 0.246), but the latter was fairly and significantly correlated with the perceived usefulness of the courses. Conclusions. The keystone of this different perception of EM versus data science was the courses' apparent value to the medical profession. The following conclusions could be drawn: (a) objective assessments of residual knowledge of the basics of data science do not necessarily correlate with the students' subjective appraisal and opinion of the field or courses; (b) medical students need to see the explicit connection between interdisciplinary or complementary courses and the medical profession; and (c) courses on information technology and data science would better suit a distributed approach across the medical curriculum.

Strengthening capacities of multidisciplinary professionals to apply data science in public health: Experience of an international graduate diploma program in Peru.

Nowadays it is necessary to strengthen health information systems and data-based solutions. However, there are few graduate training programs in Peru to use tools and methods of data science applied in public health. This article describes the development process and the initial assessment regarding the experience of the participants in an international multidisciplinary diploma in data intelligence for pandemics and epidemics preparedness, which was carried out from January to May 2021. The diploma was structured in 7 modules and 40 Peruvian professionals participated, of which 11 (27.5%) were women, and 16 (40%) came from regions outside of Lima and Callao. We discussed the need to strengthen institutional and health professionals' capacity to adequately manage large volumes of data, information, and knowledge through the application of emerging technologies to optimize data management processes to improve decision-making in health.

Developing a population data science approach to assess increased risk of COVID-19 associated with attending large events.

Introduction: In summer 2021, as rates of COVID-19 decreased and social restrictions were relaxed, live entertainment and sporting events were resumed. In order to inform policy on the safe re-introduction of spectator events, a number of test events were organised in Wales, ranging in setting, size and audience. Objectives: To design and test a method to assess whether test events were associated with an increase in risk of confirmed COVID-19, in order to inform policy. Methods: We designed a cohort study with fixed follow-up time and measured relative risk of confirmed COVID-19 in those attending two large sporting events. First, we linked ticketing information to individual records on the Welsh Demographic Service (WDS), a register of all people living in Wales and registered with a GP, and identified NHS numbers for attendees. Where NHS numbers were not found we used combinations of other identifiers such as email, name, postcode and/or mobile number. We then linked attendees to routine SARS-CoV-2 test data to calculate positivity rates in people attending each event for the period one to fourteen days following the event. We selected a comparison cohort from WDS for each event, individually matched by age band, gender and locality of residence. As many people attended events in family groups we explored the possibility of also matching on household clusters within the comparison group. Risk ratios were then computed for the two events. Results: We successfully assigned NHS numbers to 91% and 84% of people attending the two events respectively. Other identifiers were available for the remainder. Only a small number of attendees (<10) had a record of confirmed COVID-19 following attendance at each event (14 day cumulative incidence: 36 and 26 per 100,000, respectively). There was no evidence of significantly increased risk of COVID-19 at either event. However, the event that didn't include pre-event testing in their mitigations, had a higher risk ratio (3.0 compared to 0.3). Conclusions: We demonstrate the potential for using population data science methods to inform policy. We conclude that, at that point in the epidemic, and with the mitigations that were in place, attending large outdoor sporting events did not significantly increase risk of COVID-19. However, these analyses were carried out between epidemic waves when background incidence and testing rate was low, and need to be repeated during periods of greater transmission. Having a mechanism to identify attendees at events is necessary to calculate risk and feasibility and acceptability of data sharing should be considered.

Socio-economic analysis of short-term trends of COVID-19: modeling and data analytics.

BACKGROUND: COVID-19 caused a worldwide outbreak leading the majority of human activities to a rough breakdown. Many stakeholders proposed multiple interventions to slow down the disease and number of papers were devoted to the understanding the pandemic, but to a less extend some were oriented socio-economic analysis. In this paper, a socio-economic analysis is proposed to investigate the early-age effect of socio-economic factors on COVID-19 spread. METHODS: Fifty-two countries were selected for this study. A cascade algorithm was developed to extract the R0 number and the day J*; these latter should decrease as the pandemic flattens. Subsequently, R0 and J* were modeled according to socio-economic factors using multilinear stepwise-regression. RESULTS: The findings demonstrated that low values of days before lockdown should flatten the pandemic by reducing J*. Hopefully, DBLD is only parameter to be tuned in the short-term; the other socio-economic parameters cannot easily be handled as they are annually updated. Furthermore, it was highlighted that the elderly is also a major influencing factor especially because it is involved in the interactions terms in R0 model. Simulations proved that the health care system could improve the pandemic damping for low elderly. In contrast, above a given elderly, the reproduction number R0 cannot be reduced even for developed countries (showing high HCI values), meaning that the disease's severity cannot be smoothed regardless the performance of the corresponding health care system; non-pharmaceutical interventions are then expected to be more efficient than corrective measures. DISCUSSION: The relationship between the socio-economic factors and the pandemic parameters R0 and J* exhibits complex relations compared to the models that are proposed in the literature. The quadratic regression model proposed here has discriminated the most influencing parameters within the following approximated order, DLBL, HCI, Elderly, Tav, CO2, and WC as first order, interaction, and second order terms. CONCLUSIONS: This modeling allowed the emergence of interaction terms that don't appear in similar studies; this led to emphasize more complex relationship between the infection spread and the socio-economic factors. Future works will focus on enriching the datasets and the optimization of the controlled parameters to short-term slowdown of similar pandemics.

Leveraging artificial intelligence and data science techniques in harmonizing, sharing, accessing and analyzing SARS-COV-2/COVID-19 data in Rwanda (LAISDAR Project): study design and rationale.

BACKGROUND: Since the outbreak of COVID-19 pandemic in Rwanda, a vast amount of SARS-COV-2/COVID-19-related data have been collected including COVID-19 testing and hospital routine care data. Unfortunately, those data are fragmented in silos with different data structures or formats and cannot be used to improve understanding of the disease, monitor its progress, and generate evidence to guide prevention measures. The objective of this project is to leverage the artificial intelligence (AI) and data science techniques in harmonizing datasets to support Rwandan government needs in monitoring and predicting the COVID-19 burden, including the hospital admissions and overall infection rates. METHODS: The project will gather the existing data including hospital electronic health records (EHRs), the COVID-19 testing data and will link with longitudinal data from community surveys. The open-source tools from Observational Health Data Sciences and Informatics (OHDSI) will be used to harmonize hospital EHRs through the Observational Medical Outcomes Partnership (OMOP) Common Data Model (CDM). The project will also leverage other OHDSI tools for data analytics and network integration, as well as R Studio and Python. The network will include up to 15 health facilities in Rwanda, whose EHR data will be harmonized to OMOP CDM. EXPECTED RESULTS: This study will yield a technical infrastructure where the 15 participating hospitals and health centres will have EHR data in OMOP CDM format on a local Mac Mini ("data node"), together with a set of OHDSI open-source tools. A central server, or portal, will contain a data catalogue of participating sites, as well as the OHDSI tools that are used to define and manage distributed studies. The central server will also integrate the information from the national Covid-19 registry, as well as the results of the community surveys. The ultimate project outcome is the dynamic prediction modelling for COVID-19 pandemic in Rwanda. DISCUSSION: The project is the first on the African continent leveraging AI and implementation of an OMOP CDM based federated data network for data harmonization. Such infrastructure is scalable for other pandemics monitoring, outcomes predictions, and tailored response planning.

Public Awareness and Sentiment toward COVID-19 Vaccination in South Korea: Findings from Big Data Analytics.

Despite a worldwide campaign to promote vaccination, South Korea is facing difficulties in increasing its vaccination rate due to negative perceptions of the vaccines and vaccination policies. This study investigated South Koreans' awareness of and sentiments toward vaccination. Particularly, this study explored how public opinions have developed over time, and compared them to those of other nations. We used Pfizer, Moderna, Janssen, and AstraZeneca as keywords on Naver, Daum, Google, and Twitter to collect data on public awareness and sentiments toward the vaccines and the government's vaccination policies. The results showed that South Koreans' sentiments on vaccination changed from neutral to negative to positive over the past two years. In particular, public sentiments turned positive due to South Koreans' hopeful expectations and a high vaccination rate. Overall, the attitudes and sentiments toward vaccination in South Korea were similar to those of other nations. The conspiracy theories surrounding the vaccines had a significant effect on the negative opinions in other nations, but had little impact on South Korea.

Building Process-Oriented Data Science Solutions for Real-World Healthcare.

The COVID-19 pandemic has highlighted some of the opportunities, problems and barriers facing the application of Artificial Intelligence to the medical domain. It is becoming increasingly important to determine how Artificial Intelligence will help healthcare providers understand and improve the daily practice of medicine. As a part of the Artificial Intelligence research field, the Process-Oriented Data Science community has been active in the analysis of this situation and in identifying current challenges and available solutions. We have identified a need to integrate the best efforts made by the community to ensure that promised improvements to care processes can be achieved in real healthcare. In this paper, we argue that it is necessary to provide appropriate tools to support medical experts and that frequent, interactive communication between medical experts and data miners is needed to co-create solutions. Process-Oriented Data Science, and specifically concrete techniques such as Process Mining, can offer an easy to manage set of tools for developing understandable and explainable Artificial Intelligence solutions. Process Mining offers tools, methods and a data driven approach that can involve medical experts in the process of co-discovering real-world evidence in an interactive way. It is time for Process-Oriented Data scientists to collaborate more closely with healthcare professionals to provide and build useful, understandable solutions that answer practical questions in daily practice. With a shared vision, we should be better prepared to meet the complex challenges that will shape the future of healthcare.

An Autoscaling Platform Supporting Graph Data Modelling Big Data Analytics.

Big Data has proved to be vast and complex, without being efficiently manageable through traditional architectures, whereas data analysis is considered crucial for both technical and non-technical stakeholders. Current analytics platforms are siloed for specific domains, whereas the requirements to enhance their use and lower their technicalities are continuously increasing. This paper describes a domain-agnostic single access autoscaling Big Data analytics platform, namely Diastema, as a collection of efficient and scalable components, offering user-friendly analytics through graph data modelling, supporting technical and non-technical stakeholders. Diastema's applicability is evaluated in healthcare through a predicting classifier for a COVID19 dataset, considering real-world constraints.

CyberPharmacovigilance of Covid-19: Social Media Data Analytics.

In this article, we present a methodology and a tool for extracting and analyzing information, reported by a social media monitor, of people who have taken drugs to treat Covid-19 and the adverse effects encountered.

The medical and societal impact of big data analytics and artificial intelligence applications in combating pandemics: A review focused on Covid-19.

With Covid-19 impacting communities in different ways, research has increasingly turned to big data analytics (BDA) and artificial intelligence (AI) tools to track and monitor the virus's spread and its effect on humanity and the global economy. The purpose of this study is to conduct an in-depth literature review to identify how BDA and AI were involved in the management of Covid-19 (while considering diversity, equity, and inclusion (DEI)). The rigorous search resulted in a portfolio of 607 articles, retrieved from the Web of Science database, where content analysis has been conducted. This study identifies the BDA and AI applications developed to deal with the initial Covid-19 outbreak and the containment of the pandemic, along with their benefits for the social good. Moreover, this study reveals the DEI challenges related to these applications, ways to mitigate the concerns, and how to develop viable techniques to deal with similar crises in the future. The article pool recognized the high presence of machine learning (ML) and the role of mobile technology, social media and telemedicine in the use of BDA and AI during Covid-19. This study offers a collective insight into many of the key issues and underlying complexities affecting public health and society from Covid-19, and the solutions offered from information systems and technological perspectives.